Selenium and total antioxidant levels in patients with intra-bronchial and extra-bronchial lung cancer
DOI:
https://doi.org/10.60988/p.v37i2S.191Keywords:
antioxidants; selenium; bronchoscopy; biomarkers; oxidative stressAbstract
This study investigates the levels of total antioxidant capacity (TAC) and selenium (Se) in patients with lung cancer treated at the Taiba Hospital for Surgical Specialties. Fifty-seven patients aged 40 to 80 years were included in the study, with samples collected through bronchoscopy between December 19, 2021, and April 11, 2022. Patients were classified into two groups based on tumour location: 24 patients with extra-bronchial tumours (EXO; group A) and 33 patients with intra-bronchial tumours (ENDO; group B). All diagnoses were confirmed by histological and cytological tests. Significant differences in TAC and Se levels were observed between the groups. The EXO group exhibited lower TAC levels (1.783 ± 4.391 units/mL) compared to the ENDO group (5.616 ± 4.915 units/mL; p=0.004). In contrast, Se levels were higher in the EXO group (95.954 ± 3.233 ppb) than in the ENDO group (84.200 ± 3.824 ppb; p<0.001). These findings reveal a strong association between tumour type and the levels of TAC and Se, suggesting their potential utility as biomarkers for the diagnosis and prognosis of lung cancer. Further research is warranted in order to explore the clinical implications of these findings for treatment and prevention strategies.
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