Improving mass transfer efficiency for penicillin production by using a continuous stirred tank reactor: a review
DOI:
https://doi.org/10.60988/p.v37i2S.258Keywords:
antibiotic; penicillin; volumetric mass transfer coefficient; continuous stirred tank reactor; drug productionAbstract
Continuous stirred tank reactors (CSTRs) play a pivotal role in the industrial production of chemicals, including antibiotics such as penicillin, due to their ability to enhance mass transfer efficiency. The CSTR’s design facilitates precise control over aeration and agitation; two critical parameters that influence the volumetric mass transfer coefficient. Aeration supports cellular metabolism by supplying oxygen, while agitation promotes the dispersion of gas bubbles, thereby improving phase contact. This review explores the historical development of penicillin, its mechanism of action, the principles underlying bioreactor operation, and the specific ways in which aeration and agitation affect mass transfer dynamics. By optimizing reactor configuration, operating conditions, and associated process parameters, producers can significantly enhance the efficiency of penicillin biosynthesis.
References
1. Haque M.A., Nath N.D., Johnston T.V., Haruna S., Ahn J., Ovissipour R., et al. Harnessing biotechnology for penicillin production: opportunities and environmental considerations. Sci. Total Environ. 946, 174236, 2024. DOI: 10.1016/j.scitotenv.2024.174236
2. Mohd-Setapar S.H., Mat H., Mohamad-Aziz S.N. Kinetic study of antibiotic by reverse micelle extraction technique. J. Taiwan Inst. Chem. Eng. 43(5), 685–695, 2012. DOI: 10.1016/j.jtice.2012.02.007
3. Fisher J.F., Mobashery S. Constructing and deconstructing the bacterial cell wall. Protein Sci. 29(3), 629–646, 2020. DOI: 10.1002/pro.3737
4. Gaynes R. The discovery of penicillin – new insights after more than 75 years of clinical use. Emerg. Infect. Dis. 23(5), 849–853, 2017. DOI: 10.3201/eid2305.161556
5. Kaur I., Sharma A.D. Bioreactor: design, functions and fermentation innovations. Res. Rev. Biotechnol. Biosci. 8(2), 34–43, 2021. DOI: 10.5281/zenodo.5775455
6. Lee D.Y., Li Y.Y., Oh Y.K., Kim M.S., Noike T. Effect of iron concentration on continuous H2 production using membrane bioreactor. Int. J. Hydrog. Energy 34(3), 1244–1252, 2009. DOI: 10.1016/j.ijhydene.2008.11.093
7. Vanags J., Suleiko A. Oxygen mass transfer coefficient application in characterisation of bioreactors and fermentation processes. Latv. J. Phys. Tech. Sci. 59(5), 21–32, 2022. DOI: 10.2478/lpts-2022-0038
8. Cooper C.M., Fernstrom G.A., Miller S.A. Performance of agitated gas-liquid contactors. Ind. Eng. Chem. 36(6), 504–509, 1944. DOI: 10.1021/ie50414a005
9. Wise W.S. The measurement of the aeration of culture media. J. Gen. Microbiol. 5(1), 167–177, 1951. DOI: 10.1099/00221287-5-1-167
10. Garcia-Ochoa F., Gomez E., Santos V.E. Fluid dynamic conditions and oxygen availability effects on microbial cultures in STBR: an overview. Biochem. Eng. J. 164, 107803, 2020. DOI: 10.1016/j.bej.2020.107803
