Emerging trends in nanopharmacology: new therapeutic approaches to paediatric parasitology
DOI:
https://doi.org/10.60988/p.v37i2S.253Keywords:
nanopharmacology; nanotechnology; nanoparticles; parasite; paediatricAbstract
New and emerging trends, particularly in the employment of nanotechnology for the treatment of paediatric parasitic infections, are transforming the therapeutic modalities of parasitic diseases that largely affect children. This review outlines how nanopharmacological methods, especially liposomal and polymeric nanoparticles, boost drug delivery systems and transform treatment options for parasitic infections in children. Emerging nanopharmacological methods can be combined with recent discoveries with practical applications in the diagnosis, vaccine development, and fighting of drug-resistant organisms. We, herein, also briefly present the novel horizons of nanopharmacology and how the advancements in the field that must overcome existing limitations (such as the development of drug resistance and the low bioavailability of several therapeutic agents) by refining the effectiveness and the selection of therapeutic solutions. The combined application of nanotechnology and paediatric parasitology could be the ultimate approach to improving the quality of paediatric health, especially in developing countries. Finally, this review highlights current and future directions for paediatric parasitology, as it handles drug resistance and enhances therapeutic effectiveness while developing better vaccine technologies.
References
1. Jasim R.A.F., Ewadh R.M.J., Al-Hindy H.A.A.M. Pediatric non-COVID community-acquired pneumonia: Correlation of etiology, innate immune responses and the impact of feeding practices. Edelweiss Appl. Sci. Technol. 8(5), 2542–2551, 2024. DOI: 10.55214/25768484.v8i5.3955
2. AlGabbani Q. Nanotechnology: a promising strategy for the control of parasitic infections. Exp. Parasitol. 250, 108548, 2023. DOI: 10.1016/j.exppara.2023.108548
3. Lu H., Zhang S., Wang J., Chen Q. A review on polymer and lipid-based nanocarriers and its application to nano-pharmaceutical and food-based systems. Front. Nutr. 8, 783831, 2021. DOI: 10.3389/fnut.2021.783831
4. Siddiqui N.A., Ansari M.Z., Sinha S.K., Pal B., Singh A.K., Singh S.K., et al. Treatment outcomes of single-dose liposomal amphotericin B-treated visceral leishmaniasis patients and factors affecting outcome in Bihar, India. Am. J. Trop. Med. Hyg. 111(6), 1198–1205, 2024. DOI: 10.4269/ajtmh.23-0640
5. Kumari P., Kumar S., Raman R.P., Brahmchari R.K. Nanotechnology: an avenue for combating fish parasites in aquaculture system. Vet. Parasitol. 332, 110334, 2024. DOI: 10.1016/j.vetpar.2024.110334
6. Parvin N., Joo S.W., Mandal T.K. Enhancing vaccine efficacy and stability: a review of the utilization of nanoparticles in mRNA vaccines. Biomolecules 14(8), 1036, 2024. DOI: 10.3390/biom14081036
7. Huang Y., Guo X., Wu Y., Chen X., Feng L., Xie N., et al. Nanotechnology’s frontier in combatting infectious and inflammatory diseases: prevention and treatment. Signal Transduct. Target. Ther. 9(1), 34, 2024. DOI: 10.1038/s41392-024-01745-z
8. Gujjari L., Kalani H., Pindiprolu S.K., Arakareddy B.P., Yadagiri G. Current challenges and nanotechnology-based pharmaceutical strategies for the treatment and control of malaria. Parasite Epidemiol. Control 17, e00244, 2022. DOI: 10.1016/j.parepi.2022.e00244
9. Tiwari R., Gupta R.P., Singh V.K., Kumar A., Rajneesh, Madhukar P., et al. Nanotechnology-based strategies in parasitic disease management: from prevention to diagnosis and treatment. ACS Omega 8(45), 42014–42027, 2023. DOI: 10.1021/acsomega.3c04587
10. Wasti S., Lee I.H., Kim S., Lee J.H., Kim H. Ethical and legal challenges in nanomedical innovations: a scoping review. Front Genet. 14, 1163392, 2023. DOI: 10.3389/fgene.2023.1163392