Protective effects of Mentha leaves’ extract against ethanol-induced liver damage and inflammatory response in mice
DOI:
https://doi.org/10.60988/p.v37i2S.231Keywords:
mint extract; anti-inflammatory effects; TNF-α; IL-6; IL-1βAbstract
The mint (Mentha spp.) leaf extract plays a pivotal role in enhancing immunological functions, notably by stimulating the activity of macrophages and natural killer cells; key components in pathogen recognition and elimination. This study aimed to investigate the anti-inflammatory properties of mint leaf extract in a murine model of ethanol-induced inflammation, with particular emphasis on its modulatory effects on major inflammatory cytokines: tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), and interleukin-1 beta (IL-1β). Male mice were randomly assigned to four groups: control, ethanol-only, and two experimental groups receiving mint extract at doses of 100 mg/kg and 200 mg/kg, respectively, in combination with ethanol for 30 consecutive days. Serum cytokine concentrations were quantified using ELISA. Ethanol administration resulted in a significant elevation of the TNF-α, IL-6, and IL-1β levels. Co-treatment with the mint extract at both 100 mg/kg and 200 mg/kg attenuated these cytokine levels, with the higher dose demonstrating a more pronounced effect. These findings indicate that the mint extract exerts a dose-dependent anti-inflammatory response and may hold therapeutic promise for mitigating ethanol-induced inflammation and other cytokine-mediated inflammatory conditions.
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