A prospective cohort study on the association between ear drop use and otomycosis: prevalence, treatment outcomes, and recurrence

Authors

  • Abdulhusein Mizhir Almaamuri

DOI:

https://doi.org/10.60988/p.v37i2S.153

Keywords:

otomycosis; ear drops; ototopical agents; fungal infection; otitis externa

Abstract

This study investigates the incidence of otomycosis associated with ear drop usage and evaluates treatment outcomes and recurrence rates in Iraqi patients with and without a recent history of ear drop application. Conducted at the ENT Clinic of Almahawil Hospital (Iraq) from April 1, 2022, to March 31, 2024, the study involved 280 patients diagnosed with otomycosis. Participants were divided into two groups: group 1 (N=72) comprised individuals who had used ear drops within 1–2 weeks prior to diagnosis, while group 2 (N=208) comprised individuals who had not recently used ear drops. Our findings revealed that 26% of otomycosis cases were linked to recent ear drop use, with ciprofloxacin being the most commonly used agent (61.1%). Both groups demonstrated high rates of symptom resolution following treatment; however, the recurrence rate was notably higher among ear drop users (11.1%) compared to non-users (7.8%). These results suggest that ear drop usage may elevate the risk of developing otomycosis and increase the likelihood of recurrence, thereby highlighting the need for judicious prescribing practices.

Author Biography

Abdulhusein Mizhir Almaamuri

College of Pharmacy, Al Mustaqbal University, Hillah, Iraq

References

Agarwal P., Devi L.S. Otomycosis in a rural community attending a tertiary care hospital: assessment of risk factors and identification of fungal and bacterial agents. J. Clin. Diagn. Res. 11(6), DC14–DC18, 2017. DOI: 10.7860/JCDR/2017/25865.10068

Viswanatha B., Naseeruddin K. Fungal infections of the ear in immunocompromised host: a review. Mediterr. J. Hematol. Infect. Dis. 3(1), e2011003, 2011. DOI: 10.4084/MJHID.2011.003

Munguia R., Daniel S.J. Ototopical antifungals and otomycosis: a review. Int. J. Pediatr. Otorhinolaryngol. 72(4), 453–459, 2008. DOI: 10.1016/j.ijporl.2007.12.005

Anwar K., Gohar M.S. Otomycosis; clinical features, predisposing factors and treatment implications. Pak. J. Med. Sci. 30(3), 564–567, 2014. DOI: 10.12669/pjms.303.4106

Ho T., Vrabec J.T., Yoo D., Coker N.J. Otomycosis: clinical features and treatment implications. Otolaryngol. Head Neck Surg. 135(5), 787–791, 2006. DOI: 10.1016/j.otohns.2006.07.008

Jackman A., Ward R., April M., Bent J. Topical antibiotic induced otomycosis. Int. J. Pediatr. Otorhinolaryngol. 69(6), 857–860, 2005. DOI: 10.1016/j.ijporl.2005.01.022

Bojanović M., Stalević M., Arsić-Arsenijević V., Ignjatović A., Ranđelović M., Golubović M., et al. Etiology, predisposing factors, clinical features and diagnostic procedure of otomycosis: a literature review. J. Fungi (Basel) 9(6), 662, 2023. DOI: 10.3390/jof9060662

Prasad S.C., Kotigadde S., Shekhar M., Thada N.D., Prabhu P., D’ Souza T., et al. Primary otomycosis in the Indian subcontinent: predisposing factors, microbiology, and classification. Int. J. Microbiol. 2014, 636493, 2014. DOI: 10.1155/2014/636493

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Published

10-10-2025

How to Cite

[1]
Mizhir Almaamuri, A. 2025. A prospective cohort study on the association between ear drop use and otomycosis: prevalence, treatment outcomes, and recurrence. Pharmakeftiki . 37, 2S (Oct. 2025). DOI:https://doi.org/10.60988/p.v37i2S.153.