Immunohistochemical investigation of vascular endothelial growth factor during the healing of gastric ulcer in female rats: experimental study
DOI:
https://doi.org/10.60988/p.v37i2S.150Keywords:
curcumin; esomeprazole; stomach; ulcer; VEGFAbstract
The current study attempts to characterize the effects of esomeprazole, curcumin, chitosan, as well as of a mixture of curcumin and chitosan on the expression of the vascular endothelial growth factor (VEGF) in gastric ulcers induced by ethanol in female rats. This study included 30 rats; their average weight ranged between 195.6 and 198.6 g, and the rats were separated into two control groups (negative and positive control groups) and four treatment groups (n=5 rats per group). All groups were treated for 5 days after last administration of distilled water or ethanol. The immunohistochemical staining for VEGF in the cells of gastric mucosa revealed a positive staining in both the control groups and all treated groups. The H-score for VEGF was found to exhibit no significant change (p>0.05) in any of the assessed groups.
References
Scott L.J., Dunn C.J., Mallarkey G., Sharpe M. Esomeprazole: a review of its use in the management of acid-related disorders. Drugs 62(10), 1503–1538, 2002. DOI: 10.2165/00003495-200262100-00006
Miner P. Jr, Katz P.O., Chen Y., Sostek M. Gastric acid control with esomeprazole, lansoprazole, omeprazole, pantoprazole, and rabeprazole: a five-way crossover study. Am. J. Gastroenterol. 98(12), 2616–2620, 2003. DOI: 10.1111/j.1572-0241.2003.08783.x
Al-Judaibi B., Chande N., Dresser G.K., Sultan N., Gregor J.C. Gastric acid-related diseases: focus on esomeprazole. Clin. Med. Insights Ther. 2, 439–452, 2010. DOI: 10.4137/CMT.S4500
Tilak J.C., Banerjee M., Mohan H., Devasagayam T.P. Antioxidant availability of turmeric in relation to its medicinal and culinary uses. Phytother. Res. 18(10), 798–804, 2004. DOI: 10.1002/ptr.1553
Devlieghere F., Vermeulen A., Debevere J. Chitosan: antimicrobial activity, interactions with food components and applicability as a coating on fruit and vegetables. Food Microbiol. 21(6), 703–714, 2004. DOI: 10.1016/j.fm.2004.02.008
Kuadkaew S., Ungphaiboon S., Phdoongsombut N., Kaewsuwan S., Mahattanadul S. Efficacy of a chitosan-curcumin mixture in treating indomethacin-induced acute gastric ulcer in rats. Curr. Pharm. Biotechnol. 22(14), 1919–1931, 2021. DOI: 10.2174/1389201022666210127115427
Alzubaidy F.M., Alzubaidy F.A., Hashim J.H., Oubaid E.N. Effects of prednisolone on the histology and histochemistry of rabbits liver and kidney. Int. J. Drug Deliv. Technol. 9(2), 217–221, 2019.
Szabo S., Khomenko T., Gombos Z., Deng X.M., Jadus M.R., Yoshida M. Review article: transcription factors and growth factors in ulcer healing. Aliment. Pharmacol. Ther. 14(s1), 33–43, 2000. DOI: 10.1046/j.1365-2036.2000.014s1033.x
Alzubaidy F.M., Bash A.A., Jasim R. Study the effect of gabapentin on the histology of some organs of male rats. Syst. Rev. Pharm. 11(9), 95–101, 2020. DOI: 10.31838/srp.2020.9.16
Wallace J.L., Dicay M., McKnight W., Dudar G.K. Platelets accelerate gastric ulcer healing through presentation of vascular endothelial growth factor. Br. J. Pharmacol. 148(3), 274–278, 2006. DOI: 10.1038/sj.bjp.0706722
