Topical HPMC/Carbopol 934 Gel for Wound Healing: Formulation and in-Vivo Evaluation
DOI:
https://doi.org/10.60988/p.v36i2.8Keywords:
HPMC, Carbopol, Gel, Skin wound, RabbitAbstract
Wound healing is a vital physiological process for preserving the integrity of the skin following trauma caused by an accident or an intentional surgery. The characteristics of hydrogels, such as their high moisture content, ability to act as a barrier against bacterial infections, and ability to provide a moist environment for wound healing, can be used for the management of oozing and granulating wounds. Moreover, hydrogel may accelerate wound healing by stimulating cell proliferation. The present study aimed to formulate and evaluate topical hydroxypropyl methylcellulose (HPMC)/carbopol 934 gels for wound healing purposes. Different formulas were prepared using each polymer alone as in F1 and F3 and a combination of them (F2). The gels were evaluated by physical characterization, pH measurement, spreadability test, scanning electron microscopy, rheological testing, and Fourier transform infrared (FTIR) spectroscopy. Furthermore, the wound healing in rabbit skin was evaluated. All formulas showed good results relating to visual appearance, pH, FTIR study, and spreadability. However, the results of the viscosity and histological studies revealed that the best formula is the one composed of 1% HPMC and 1% carbopol 934. This product will eventually meet all standards for evaluation in preclinical and clinical studies.
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