Ethnomedicinal and Possible Mechanism of Anticancer Properties of Elephant Foot - A Review
DOI:
https://doi.org/10.60988/p.v37i2.78Keywords:
Elephant foot, Anticancer agent,, Traditional medicine, Immune response.Abstract
Elephant foot (Elephantopus scaber Linn.), a medicinal plant widely used in traditional medicine, holds significant promise as a potential anticancer agent. Ethnomedicinal practices across various countries employ E. scaber extracts for their anti-inflammatory, antipyretic, diuretic, anticough, antibiotic, emollient, and tonic properties. Recent scientific investigations have shed light on several mechanisms through which E. scaber exhibits anticancer effects. These include the induction of apoptosis (programmed cell death), inhibition of cell proliferation, suppression of angiogenesis (formation of new blood vessels essential for tumour growth), and modulation of signalling pathways crucial for tumour progression. Additionally, the plant’s antioxidant properties play a role in protecting cells from oxidative stress-induced damage, a common feature in cancer development. Furthermore, E. scaber has been shown to enhance the immune response against cancer cells, adding another layer to its anticancer potential. It also demonstrates synergistic interactions with conventional chemotherapy drugs, potentially improving their efficacy and reducing side effects. The plant’s diverse pharmacological properties, combined with its traditional use, underscore its value as a natural resource with significant anticancer potential. Overall, Elephant foot represents a promising avenue for the development of novel anticancer therapies, warranting further research and exploration.
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