Effect of Melatonin on Body Weight and Hormones in Male Rats
DOI:
https://doi.org/10.60988/p.v37i2.74Keywords:
Melatonin, Body weight, Insulin, Growth hormone, ACTH, MetabolismAbstract
Background and objectives: Melatonin is a neurohormone secreted mainly by the pineal gland, where it is synthesized and secreted at night. Many research studies have shown that melatonin supplementation enhanced growth hormone secretion in rats, from this point the current research aimed to explore the effect of melatonin on other hormones and some endogenous substances related to metabolism. Methods: Current study uses 30 rats distributed into 3 groups; T1 group: 10 Rats were treated with melatonin (0.4 mg/kg) as a therapeutic dose, T2 group: 10 Rats were treated with melatonin (0.8 mg/kg) as double dose and T0 group: 10 Rats were administered distilled water as a control group. Results: The results showed that there was a statistically significant (P<0.01) variance in physiological parameters. At the same time, the administration of melatonin in double dose (T2 group) revealed a significant (P<0.01) reduction in body weight (189.20 g) at the end of the experiment when compared with another group as well as with zero time. Insulin showed a significant (P<0.01) increase in the T2 group (112.99 µIU/mL) when compared with another group. Also, the results showed there is an oblivious role of melatonin in inhibiting the secretion of the ACTH hormone, especially in the T2 group by revealing a significant reduction (P<0.01) of ACTH level in the T2 group (6.97 pg/ml). Further, results revealed a significant (P<0.01) increase in GH clearly in the T2 group (39.36 pmol/L). Conclusion: Melatonin has a negative effect on hormones that are responsible for normal growth and metabolism and may explain why melatonin is involved in regulating obesity in various species as well this effect may extend to humans and imitate loss of body weight when spent chronically for children.
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