Eudragit Nanofiber for Effective Coating in Colon-Targeted Drug Delivery
DOI:
https://doi.org/10.60988/p.v37i1.72Keywords:
Eudragit nanofibers, colon-targeted drug delivery, electrospinning, pH-responsive polymers, in vitro studies, in vivo studies, inflammatory bowel disease, colorectal cancer, mucoadhesion, controlled release.Abstract
Eudragit nanofiber-based drug delivery systems offer a novel and promising solution for colon-targeted therapies. This review extensively covers the unique properties, fabrication methods, and therapeutic applications of Eudragit nanofibers in treating colonic diseases. Known for their pH-responsive solubility, Eudragit polymers enable targeted drug release in the colon, protecting the drug from early release in the stomach’s acidic environment. The electrospinning process, essential for creating Eudragit nanofibers, facilitates high drug loading and controlled, sustained release. In vitro studies have shown these nanofibers’ effective drug release, mucoadhesive properties, and permeability. In vivo animal studies demonstrate promising targeting efficiency, biodistribution, and therapeutic efficacy, especially for inflammatory bowel disease (IBD), colorectal cancer, and colonic infections. Despite their advantages, challenges remain, including maintaining consistent fiber morphology, scaling up production, and navigating regulatory hurdles. Nonetheless, the benefits—such as enhanced therapeutic efficacy, reduced systemic side effects, and better patient compliance—highlight Eudragit nanofibers as a superior option for advanced drug delivery. Future research should focus on developing smart, responsive nanofiber systems, personalized medicine approaches, and exploring new therapeutic applications. This review highlights the transformative potential of Eudragit nanofibers in colon-targeted drug delivery, aiming to improve treatment outcomes for patients with colonic disorders.
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