Inhalable Mucoadhesive Nanoparticles of Favipiravir as Drug Delivery Systems to the Lungs in Dry Powder Formulations
Inhalable Mucoadhesive Nanoparticles of Favipiravir
DOI:
https://doi.org/10.60988/p.v37i1.66Keywords:
Favipiravir, Poly(lactic-co-glycolic acid), Chitosan, Mucoadhesive, Dry Powder Inhaler, Epithelial cells integrityAbstract
The drug delivery to the systemic via inhalation route is the best alternative for parenteral or oral drug delivery. The drug reaches to lungs through the inhalation technique has a lot of advantages, such as the rapid onset of action, high bioavailability, improved patient compliance, self-administration, non-invasive nature and less drug degradation due to bypass first-pass metabolism . This work aimed to develop favipiravir mucoadhesive nanoparticles and deliver them through a dry powder inhaler, which could be the alternative route for administering favipiravir. The nanoparticles have been prepared by the nanoprecipitation method using poly(lactic-co-glycolic acid) and chitosan as biodegradable and mucoadhesive polymers. An X-ray diffractometer was utilized to identify the crystalline changes of favipiravir in the nanoparticle, and the physical status was tested by Differential scanning calorimeter analysis. The prepared nanoparticle has a spherical shape with 104.6 nm size and a zeta potential of -12.7 mV. The nanoparticle has 72.06% entrapment efficiency with significant, sustained drug release of 85.1% at 48 h. The mucoadhesive nanoparticle showed negligible damage in epithelial integrity with dry powder inhaler emitted a dose of 87.02% and mass median aerodynamic diameter of 2.90 μm. The prepared nanoparticle showed a significant mucoadhesive strength of 77.1% with lung mucosa. Favipiravir mucoadhesive nanoparticle-loaded dry powder inhaler could be the best route for administration of COVID-19 patients.
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