Papain: a promising enzyme with bactericidal, anti-inflammatory action for dermal and dental applications
DOI:
https://doi.org/10.60988/p.v36i3.50Keywords:
papain, enzyme, wound healing, dental applicationAbstract
The management of acute and chronic wounds has a significant financial, clinical, social impact on healthcare and affects the living conditions of over 2.5% of the population. Despite the numerous treatments, already established, for both chronic and acute wounds, their management continues to constitute an urgent and burdensome issue in modern times, necessitating the development of novel therapies. The most powerful catalysts found in nature are enzymes. Proteases are among the most highly lucrative commercial enzymes and account for around 60% of the entire enzyme market. The first protein to be obtained from papaya and the first cysteine protease whose three-dimensional X-ray analysis showed its structure was papain. As a result, cysteine proteases, a major category of essential substances, are acknowledged as papain-like proteins. Thus, papaya (Carica papaya) and mountain papaya (Vasconcellea cundinamarcensis) both contain the cysteine protease enzyme known as papain, also referred to as papaya proteinase I. This mini review's objective is to look into the literature for healing properties of papain attributed to its bactericidal and anti-inflammatory action.
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