Pharmacological Exploration of in Vitro Antibacterial and in Vivo Wound Healing Using Basella Alba Ethanolic Stem Extract Ointment On Rats

Abstract

The present study was undertaken to determine the in vivo wound healing activity and in vitro antibacterial activity of Basella alba stem. Wound healing activity was evaluated using burn wound model in rats. Wound healing is a complex phenomenon which consists of three stages that includes inflammatory,proliferative, and remodelling.Traditionally Basella alba is used for wound healing. There is no specific scientific data available for the wound healing activity of Basella alba stem. The wound healing activity of Ethanolic Stem Extract of Basella alba was evaluated by burn wound models. The parameters studied includes the epithelialisation period and rate of wound contraction. It also possess antibacterial activity. Ethanolic Stem Extractof Basella alba was tested against both gram positive and gram negative bacteria using agar well diffusion method. From the results, it was concluded that Ethanolic Stem Extract of Basella alba has significant wound activity and antibacterial activity .