Latin Square Design For Selection of Excipients in the Development of the Composition of Medical Sponges Based on the Cryoliophylized Xenoderm
DOI:
https://doi.org/10.60988/p.v36i1.47Keywords:
medical sponges, xenoderm powder, Latin squares design, drug technology, excipients.Abstract
Medical sponges are popular medical tools, which widely used in various fields of medicine to stop bleeding and for close wound surfaces. Therefore, the aim of our work was to study the selection of excipients in order to develop the composition and technology of medical sponges based on a material of biological origin - cryolyophilized xenoderm, which has wide practical application in combustiology.
The influence of three groups of factors on the technological parameters of 16 experimental series of the sponges was studied. The indicators: pH, appearance, water absorption, time of complete dissolution, In vitro degradation, thickness of sponges, and weight loss during drying.
The influence of factors and their levels on the quality indicators of the developed medical sponges is investigated. It is established that the influence of the type of polymer is decisive for all characteristics except for weight loss during drying, which is more influenced by the type of plasticizer. Using the generalized indicator - the desirability function, the optimal levels of factors within each factor are selected.
According to the results of the tests, it was found that the best values of technological indicators were medical sponges based on water extract obtained at 40° C, which included medical gelatin and propylene glycol.
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