Augue toxicity test and anapathological study of Hyoscyamus muticus subsp falezlez (Coss) Maire
DOI:
https://doi.org/10.60988/p.v36i3.41Abstract
Hyoscyamus muticus subsp falezlez (Coss) is a toxic species, highly responded to in the Algerian Sahara, and played an important role in the traditional medicine of the Tuareg. It is one of the Solanaceae richest in tropanic alkaloids (especially atropine), which constitute a large group of secondary metabolites.
The objective was to study its toxicity to exploit the data in the valorisation of this endemic species.
The acute toxicity study and the calculation of the LD50 were carried out on Wistar mice and using the tinctures of the plant collected from the Adrara Sbaa station (southwest of Algeria). A pathological examination of the organs after the mice dissection was carried out.
LD50 determination from the plant tinctures confirmed its extreme toxicity and was estimated at 0.85± 0.27g/kg dry plant. Functional abnormalities were detected in the heart and liver of mice injected with the lethal dose (6.3g/kg); significant vasodilation was observed.
Content of the results obtained, it is imperative to explore this species and value it as an industrial source of atropine production in Algeria.
Key words: Hyoscyamus, Toxicity, anapathology, Algeria
