Titrimetric semi-micro determination of sodium metamizole with Potassium hydrogenperoxymonosulphate
DOI:
https://doi.org/10.60988/p.v36i3.4Keywords:
sodium metamizole, potassium hydrogenperoxomonosulphate (oxone), iodometric, quantitation, tabletsAbstract
A simple, rapid and accurate titrimetric procedure using potassium hydrogenperoxymonosulphate have been developed for the semi-micro determination of sodium metamizole in pure form and in tablets. The proposed method is based on the oxidation of bisulfite ions formed as a result of acid hydrolysis of sodium metamizole by known excess of the potassium hydrogenperoxomonosulphate with the following determination of the residual oxidant by iodometric titration. The optimum reactions conditions and other analytical parameters are evaluated. The influence of the substrates commonly employed as excipients with sodium metamizole has been studied. Statistical comparison of the results with those of an official method shows excellent agreement and indicates no significant difference in precision. RSD ≤1.49%; (δ =0.49 - 0.84%). LOQ=0.01 mg.
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