The study of prostate-protective effect of dry ex- tract from reishi mushrooms on the model of testosterone-induced prostatic hyperplasia
DOI:
https://doi.org/10.60988/pj.v35i4.31Abstract
The aim of this work was to study the prostate-protective properties of dry extract from reishi mushrooms in testosterone-induced benign prostatic hyperplasia in rats.
Materials and methods. Simulated benign prostatic hyperplasia was reproduced by subcutaneous injection of testosterone propionate solu- tion at a dose of 3 mg/kg to male rats for 21 days.
The dry extract of reishi mushrooms was administered intragastrically to experimental animals daily at a dose of 100 mg/kg body weight simultaneously with subcutaneous injection of testosterone propionate for 3 weeks. The comparison drug «Prostatophyt” in a dilution of 1:10 at a dose of 1 ml/100 g of the animal’s body weight was administered intragastrically according to the same scheme as the reishi extract. Prostate homogen- ate and rat blood serum were tested.
The prostate-protective effect of the reishi mushroom extract was evaluated by the activity of acid and alkaline phosphatase, the content of TBА-active products and reduced glutathione. The phosphatase index was calculated, which is the ratio of acid phosphatase to alkaline phosphatase (AP/ALP).Results.
Subcutaneous administration of testosterone propionate to male rats for 21 days probably leads to disruption of phosphatases activity, increase in TBA-active products and decrease in the content of re- duced glutathione in blood serum and prostate homogenate of affected animals.It was established that the dry extract from reishi mushrooms in the model of testosterone-induced benign prostatic hyperplasia in white rats inhibits the processes of lipid peroxidation and normalizes the antioxidant/prooxidant balance.
Conclusion. Dry extract from reishi mushrooms has a prostate-protective effect in conditions of testosterone-induced prostate adenoma due to its antioxidant properties, which are caused by the presence of biologically active substances in mushrooms, in particular polysaccharides, flavonoids, vitamin C and steroid compounds.
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