Antidiabetic effect of Glycyrrhizin glabra extract and Glycyrrhiza glabra Silver nanoparticle in female rats
DOI:
https://doi.org/10.60988/p.v36i3.20Keywords:
Diabetes mellitus, Glycyrrhiza glabra, Silver nanoparticle, Alloxan, NicotinamideAbstract
Objective: To study the antidiabetic effect of Glycyrrhiza glabra ethanolic extract and Glycyrrhiza glabra Silver nanoparticle against induced Diabetes mellitus (D.M) by alloxan and nicotinamide in adult female Rats. Methods: The current study was performed on 36 d in which the G. glabra extract (40 mg/ Kg) and G. glabra extract loaded on Silver nanoparticle (40 mg/ Kg) were given to alloxan and nicotinamide (150mg/kg, 50 mg/kg respectively at single dose I.P.) induced diabetic rats. The antidiabetic effect has been evaluated biochemically. Results: The results of induction of D.M for 36 days showed a significant increase (P˂0.05) in serum Glucose concentration with a significant decrease (P˂0.05) in serum insulin concentration in D.M induced (G2) group when compared with the control group (G1). and showed a significant decrease (P˂0.05) in the serum glucose concentration and a significant increase (P˂0.05) of serum insulin concentration in (G3) group (received G. glabra extract) and (G4) group (G.glabra loaded on silver nanoparticle) in comparison with G2. Conclusion: This study concluded that Glycyrriza glabra extract and Glycyrrhiza glabra Silver nanoparticle have a significant antidiabetic effect induced by alloxan and nicotinamide.
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