Mupirocin-Loaded Niosomal Gel for Topical Wound Healing Application
DOI:
https://doi.org/10.60988/pj.v35i3.15Keywords:
Wound healing; Nanomedicine; Niosomes; Mupirocin gel; Niosomal geAbstract
Advanced technology is required to overcome wound healing issues in an improved manner. Mupirocin loaded niosomal gel has been developed to enhance the drug deposition for a longer period at the targeted site and sustained the rate of release of the drug. Mupirocin is a very efficient antibiotic against a variety of bacteria and pathogens, most of ten those that cause primary and secondary skin infections. The lipid hydration technique is employed to formulate niosome with polymers (Carbopol and Chitosan) at various concentrations. Those polymers are used in the formulation to sustain the rate of release of the active drug mupirocin and also provide viscosity and non-toxic, biodegradable, and biocompatible properties. Tween 80 is a non ionic surfactant utilized in the formulation to improve the entrapment efficiency of the drug. Cholesterol is utilized in the formulation to improve vesicle stability and glycerin is a gelling and moistening agent. In addition, to improve the stability of the niosomal gel methylparaben is also added to the current formulation. Fourier transform infrared(FTIR) and differential scanning calorimetry (DSC) studies are used to find out the compatibility study of the drug and other excipients. The post evaluation studies confirm that yield percentage lies between 85 - 93%, entrapment efficiency 83- 97%, drug content lies within the limit of 87 – 98%, pH range matches the skin pH and the obtained range is 6.25 - 7.3. Viscosity and Spread- ability show the result within the limit of 410 - 560 cps and 3.8 - 5.4 g cm/s respectively. Post evaluation study further subjected to in-vitro diffusion study and formulation F5 has shown best formulation sustain the drug release till 98% at 12h. The formulation F5 has shown better sustained release of active drug which contains a higher ratio of carbopol and tween 80. It was concluded that a higher concentration of tween 80 increases the entrapment efficiency of active drug in the niosome and carbopol helps to sustain the release rate to an optimum period as a swellable gelling agent.
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