Role of Vitamins and Minerals in Treating Certain Health Conditions: A Review of Current Opinion

Authors

  • Girija S. Singh

DOI:

https://doi.org/10.60988/pj.v35i3.14

Keywords:

Vitamins; minerals; cardio-vascular diseases; diabetes; cancer; immune system; osteoporosis; COVID-19; HIV.

Abstract

The role of vitamins and minerals is considered of paramount importance in management of human health. The per day dietary requirement of vitamins and minerals have been standardized. The deficiency diseases have also been spelt out. The excess of some of these supplements is also documented to cause health problems. The correct quantity required for human being has always been subject of discussion. The aim of this review article is to present an overview of the latest opinion of experts in the subject area. The review articles and research papers on effects of vitamins and minerals on certain diseases, e.g., cardiovascular disease, cancer, diabetes, weak immune system response, HIV/AIDS, COVID19, and osteoporosis, were consulted. The present article gives a brief idea about vitamins and mineral, their daily requirement, deficiency diseases and critically examines the current views on effect of vitamins and minerals on health conditions mentioned.

Author Biography

Girija S. Singh

Chemistry Department, University of Botswana, Private Bag: 0022, Gaborone, Botswana.
Email: singhgs@ub.ac.bw

References

Ford J. A., MacLennan G.S., Avenell A., Bolland M., Grey A., Witham M. For the RECORD Trial Group. Cardiovascular disease and vitamin D supple- mentation: trial analysis, systematic review, and meta-analysis. Am. J. Clin. Nutr. 100,746-55, 2014. doi:10.3945/ajcn.113.082602

O’Brien S. K. , Malacova E., Sherriff J. L., Black L. J.

The prevalence and predictors of dietarysupple- ment use in the Australian population. Nutrients 9, E1154, 2017. doi:10.3390/nu9101154

Semba R. D. The discovery of the vitamins.

Int. J. Vitam. Nutr. Res. 82(5), 310-5, 2012. doi:

1024/0300-9831/a000124

Piro A., Tagarelli G., Lagonia P., Tagarelli A., Quattro- ne A. Casimir Funk: his discovery of the vitamins and their deficiency disorders. Ann. Nutr. Metab.

(2), 85-8, 2010.

https://en.wikipedia.org/wiki/Mineral_(nutrient), accessed on October 1, 2022.

Bruice, Essential Organic Chemistry

https://www.hsph.harvard.edu/nutritionsource/

vitamins, accessed on September 26, 2022.

https://www.nhsinform.scot/healthy-liv- ing/food-and-nutrition/eating-well/vita- mins-and-minerals, accessed on December 13,

Zhang F. F., Barr S.I., McNulty H., Li D., Health effects of vitamin and mineral supplements. British Med. J.

m2511, 2020. doi: 101136/bmj.m2511

Saljoughian M. Hypervitaminosis: a global concern.

US. Pharm. 46 (10), 47-50, 2021.

Moyer V. A., US Preventive Services Task Force.Vi- tamin D and calcium supplementation to prevent fractures in adults: U.S. Preventive Services Task Force recommendation statement. Ann. Intern. Med.

(9), 691-96, 2013. doi: 10.7326/0003-4819-

-9-201305070-00603

Jenkins D. J. A., Spence J. D., Giovannucci E. L., Kim Y-I., Josse R., Vieth R., et al. Supplemental vitamins and minerals for CVD prevention and treatment. J. Am. Coll. Cardiol. 71, 570-84, 2018. doi:10.1016/j. jacc.2018.04.020

Martí-Carvajal A. J., Solà I., Lathyris D., Dayer M.

Homocysteine-lowering interventions for prevent- ing cardiovascular events. Cochrane Database Syst. Rev. 8, CD006612, 2017. doi:10.1002/14651858. CD006612.pub5

Sesso H. D., Buring J. E., Christen W. G., Kurth T, Bel- anger C, MacFadyen J, et al. Vitamins E and C in the prevention of cardiovascular disease in men: the Physicians’ Health Study II randomized controlled trial. JAMA 300, 2123-33, 2008. doi:10.1001/ jama.2008.600

Manson J. E., Cook N.R., Lee I.M., et al, VITAL Re- search Group. Vitamin D supplements and pre- vention of cancer and cardiovascular disease. N. Engl. J. Med. 380, 33-44, 2019. doi:10.1056/NEJ- Moa1809944

Hsia J., Heiss G., Ren H., Allison M., Dolan N.C., Green- land P., et al. Women’s health initiative investigators. Calcium/vitamin D supplementation and cardi- ovascular events. Circulation 115, 846-54, 2007. doi:10.1161/CIRCULATIONAHA.106.673491

Scragg R., Stewart A. W., Waayer D., Lawes C. M. M., Toop L., Sluyter J., et al. Effect of monthly high-dose vitamin D supplementation on cardiovascular dis- ease in the Vitamin D Assessment Study: a rand- omized clinical trial. JAMA Cardiol. 2, 608-16, 2017. doi:10.1001/jamacardio.2017.0175

Alpha-Tocopherol, Beta Carotene Cancer Preven- tion Study Group. The effect of vitamin

E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N.

Engl. J. Med. 330:1029-35, 1994. doi:10.1056/ NEJM199404143301501

Omenn G. S., Goodman G. E., Thornquist M. D., et al.

Effects of a combination of beta carotene and vita- min A on lung cancer and cardiovascular disease. N. Engl. J. Med. 334, 1150-5, 1996. doi:10.1056/ NEJM199605023341802

Moyer V. A., US Preventive Services Task Force. Vi- tamin, mineral, and multivitamin supplements for the primary prevention of cardiovascular disease

and cancer: US Preventive Services Task Force rec- ommendation statement. Ann. Intern. Med. 160,

-564, 2014. doi:10.7326/M14-0198

O’Connor E. A., Evans C. V., Ivlev I., Rushkin M. C., Thomas R. G., Martin A., et al. Vitamin and mineral supplements for the primary prevention of cardio- vascular disease and cancer. JAMA 327, 2334-2347,

doi:10.1001/jama.2021.15650

Manson J. E., Cook N.R., Lee I.M., et al, VITAL Re- search Group. Vitamin D supplements and pre- vention of cancer and cardiovascular disease. N. Engl. J. Med. 380, 33-44, 2019. doi:10.1056/NEJ- Moa1809944

Vollset S. E., Clarke R., Lewington S., Ebbing M., Halsey J., Lonn E., et al, B-Vitamin Treatment Trial- ists’ Collaboration. Effects of folic acid supplemen- tation on overall and site-specific cancer incidence during the randomised trials: meta-analyses of data on 50,000 individuals. Lancet 381, 1029- 36, 2013. doi:10.1016/S0140-6736(12)62001-7

Manson J. E., Bassuk S. S., Buring J. E., VITAL Re- search Group. Principal results of the vitamin D and omega-3 trial (VITAL) and updated meta-anal- ysesof relevant vitamin D trials. J. Steroid Biochem. Mol. Biol. 198, 105522, 2020. doi:10.1016/j.js- bmb.2019.105522

Zhang Z.-H., Liu M. D., Yao K., Xu S., Yu D.-X., Xie D.- D., Xu D.-X., Vitamin D deficiency aggravates growth and metastasis of prostate cancer through promot- ing EMT in two β-catenin-related mechanisms. J. Nutr. Biochem. 111, 109177, 2023. doi: 10.1016/j. jnutbio.2022.109177

Klein E. A., Thompson I. M. Jr., Tangen C. M., Crowley J. J., Lucia M. S., Goodman P. J., et al. Vitamin E and the risk of prostate cancer: the Selenium and Vita- min E Cancer Prevention Trial (SELECT). JAMA 306,

-56, 2011. doi:10.1001/jama.2011.1437

Mason J. B. Folate, cancer risk, and the Greek god, Proteus: a tale of two chameleons. Nutr.Rev. 67, 206-

, 2009. doi:10.1111/j.1753-4887.2009.00190.x

Cole B. F., Baron J. A., Sandler R. S., Haile R. W., Ah- nen D. J., Bresalier R. S., et al, Polyp Prevention Study Group. Folic acid for the prevention of colorectal adenomas: a randomized clinical trial. JAMA 297,

-9, 2007. doi:10.1001/jama.297.21.2351

Mohseni S., Tabatabaei-Malazi O., Ejtahed H.-S., Qorbani M., Azadbhakt L., Khashayar P., Larijani B., Effect of vitamins C and E on cancer survival; a systematic review. DARU J. Pharm. Sci. 30, 427-441,

doi:10.1007/s40199-022-00451-x

Song Y., Cook N. R., Albert C. M., Van Denburgh M., Manson J. E. Effects of vitamins C and E and beta- carotene on the risk of type 2 diabetes in women at high risk of cardiovascular disease: a randomized controlled trial. Am. J. Clin. Nutr. 90, 429-37, 2009. doi:10.3945/ajcn.2009.27491

Seida J. C., Mitri J., Colmers I. N., Majumdar S. R., Da- vidson M. B., Edwards A. L., et al. Clinical review: Effect of vitamin D3 supplementation on improv- ing glucose homeostasis and preventing diabetes: a systematic review and meta-analysis. J. Clin. En- docrinol. Metab. 99, 3551-60, 2014. doi:10.1210/ jc.2014-2136

Pittas A. G., Dawson-Hughes B., Sheehan P., Ware J.

H., Knowler W. C., Aroda V. R., et al, D2d Research Group. Vitamin D supplementation and preven- tion of type 2 diabetes. N. Engl. J. Med. 381, 520-30,

doi:10.1056/NEJMoa1900906

Valdés-Ramos R., Guadarrama-Lopez A. L., Martin- ez-Carrillo B. E., Benitez-Arciniega A. D., Vitamins and type 2 diabetes mellitus Endocr. Metab. Im- mune. Disord. Drug. Targets. 15, 54–63, 2015. doi:

2174/1871530314666141111103217

Samantha M., Kimballa, J. C., Emery, H., Lew- anczukc, R. Z. Effect of a vitamin and mineral sup- plementation on glycemic status: Results from a community-based program. J. Clin. Transl. Endo- crinol., 10, 28-35, 2017. https://doi.org/10.1016/j. jcte.2017.11.002

https://www.medicalnewstoday.com/articles/ do-supplements-really-benefit-the-immune-sys- tem

Mora J. R., Iwata M., von Andrian U. H., Vitamins ef- fect on the immune system: vitamins A and D take center stage. Nat. Rev. Immunol. 8, 685–98, 2008. doi: 10.1038/nri2378.

Fantacone M. L., Lowry M. B., Uesugi S. L., Michels A.

J., Choi J., Leonard S. W., The effect of multivitamin

mineral supplement on immune function in healthy older adults: a double-blind randomized con- trolled trial. Nutrients 12, 2447, 2020. doi:10.3390 nu12082447

Singhal N., Austine .J, A clinical review of micronu- trients in HIV infection, J. Int. Assoc. Phys. AIDS Care

, 63-75, 2002.

Fawzi W. W., Msamanga G. I., Spiegelman D., Wei R., Kapiga S., Villamor E., A randomized trial of multi- vitamin supplements and HIV disease progression and mortality. N. Engl. J. Med., 351, 23-32, 2004 doi:

1056/NEJMoa040541

Heid M. https://www.webmd.com/hiv-aids hiv-vi- tamins-supplements, accessed on February 1,

Visser M. E., Durao S., Sinclair D., Irlam J. H., Sieg- fried N., Micronutrient supplementation in adults with HIV infection, Cochren Database of Systematic Rev. 5, CD003650, 2017. doi: 10.1002/14651858. CD003650.pub4

Singh G. S. An overview of common chemothera- peutics used in COVID-19 illness from pharmaceu- tical chemistry point of view.

Speakman L. L., Michienzi S. M., Badowski M. E Vita- mins, supplements and COVID-19: a review of cur- rently available evidence Drugs Context. 10, 2021-6-

, 2021. doi: 10.7573/dic.2021-6-2

Zhao J. G., Zeng X. T., Wang J., Liu L.. Association be- tween calcium or vitamin D supplementation and fracture incidence in community-dwelling older adults: a systematic review and metaanalysis. JAMA

, 2466-82, 2017. doi:10.1001/jama.2017.19344

Yao P,, Bennett D,, Mafham M,, et al. Vitamin D and calcium for the prevention of fracture: a system- atic review and meta-analysis. JAMA Netw. Open

, e1917789, 2019. doi:10.1001/jamanetworko- pen.2019.17789

Burt L. A., Billington E. O., Rose M. S., Raymond D.

A., Hanley D. A., Boyd S. K.. Effect of high-dose vita- min D supplementation on volumetric bone density and bone strength: a randomized clinical trial. JAMA322, 736-45, 2019. doi:10.1001/jama.2019.11889

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Published

14-09-2023

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